Sale!

IGF-1 DES 1,3

In stock

$76.99$99.99

Concentration
1 mg per vial
Purchase this product now and earn 77 Points!

This product is prepared for LABORATORY RESEARCH USE ONLY and may not be used for other purposes.

-
+

Free & Fast
Shipping

Earn
Rewards

Excellent
Service

Properties

Molecular Formula C319H495N91O96S7
Molecular Weight 7365.4225
Physical Appearance Fine White Lyophilized Powder
Stability Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C

Identifiers

CAS 112603-35-7
InChI InChI=1S/C319H495N91O96S7/c1-31-162(20)250-308(500)404-249(161(18)19)306(498)390-214(135-245(443)444)285(477)371-193(97-102-241(435)436)269(461)396-225-152-513-512-150-223-296(488)386-213(134-244(441)442)286(478)379-199(120-155(6)7)274(466)366-185(73-52-109-341-316(331)332)261(453)365-187(75-54-111-343-318(335)336)263(455)377-198(119-154(4)5)275(467)370-192(96-101-240(433)434)266(458)372-194(103-117-507-30)270(462)380-208(130-178-85-91-181(421)92-86-178)282(474)397-222(294(486)355-167(25)310(502)408-114-57-79-228(408)300(492)387-200(121-156(8)9)276(468)374-195(69-45-48-105-321)311(503)409-115-58-77-226(409)298(490)353-165(23)254(446)361-183(68-44-47-104-320)264(456)391-216(143-412)289(481)356-168(26)313(505)506)149-510-509-148-221(400-307(499)248(160(16)17)403-288(480)209(127-175-66-42-35-43-67-175)381-267(459)189(93-98-230(323)422)369-273(465)197(118-153(2)3)376-255(447)164(22)352-272(464)212(133-243(439)440)389-305(497)247(159(14)15)402-287(479)202(123-158(12)13)378-268(460)191(95-100-239(431)432)362-253(445)163(21)351-233(425)136-347-258(450)220(395-277(469)201(122-157(10)11)388-302(494)246(326)169(27)416)147-508-511-151-224(399-297(225)489)295(487)384-205(125-173-62-38-33-39-63-173)279(471)367-188(76-55-112-344-319(337)338)265(457)392-219(146-415)293(485)398-223)259(451)348-138-235(427)359-211(132-242(437)438)284(476)363-182(71-50-107-339-314(327)328)256(448)345-137-234(426)358-204(124-172-60-36-32-37-61-172)278(470)382-207(129-177-83-89-180(420)90-84-177)280(472)383-206(126-174-64-40-34-41-65-174)281(473)385-210(131-232(325)424)283(475)375-196(70-46-49-106-322)312(504)410-116-59-80-229(410)301(493)406-252(171(29)418)304(496)349-140-236(428)357-203(128-176-81-87-179(419)88-82-176)257(449)346-139-237(429)360-215(142-411)290(482)393-218(145-414)292(484)394-217(144-413)291(483)368-186(74-53-110-342-317(333)334)262(454)364-184(72-51-108-340-315(329)330)260(452)354-166(24)309(501)407-113-56-78-227(407)299(491)373-190(94-99-231(324)423)271(463)405-251(170(28)417)303(495)350-141-238(430)401-250/h32-43, 60-67, 81-92, 153-171, 182-229, 246-252, 411-421H, 31, 44-59, 68-80, 93-152, 320-322, 326H2, 1-30H3, (H2, 323, 422)(H2, 324, 423)(H2, 325, 424)(H, 345, 448)(H, 346, 449)(H, 347, 450)(H, 348, 451)(H, 349, 496)(H, 350, 495)(H, 351, 425)(H, 352, 464)(H, 353, 490)(H, 354, 452)(H, 355, 486)(H, 356, 481)(H, 357, 428)(H, 358, 426)(H, 359, 427)(H, 360, 429)(H, 361, 446)(H, 362, 445)(H, 363, 476)(H, 364, 454)(H, 365, 453)(H, 366, 466)(H, 367, 471)(H, 368, 483)(H, 369, 465)(H, 370, 467)(H, 371, 477)(H, 372, 458)(H, 373, 491)(H, 374, 468)(H, 375, 475)(H, 376, 447)(H, 377, 455)(H, 378, 460)(H, 379, 478)(H, 380, 462)(H, 381, 459)(H, 382, 470)(H, 383, 472)(H, 384, 487)(H, 385, 473)(H, 386, 488)(H, 387, 492)(H, 388, 494)(H, 389, 497)(H, 390, 498)(H, 391, 456)(H, 392, 457)(H, 393, 482)(H, 394, 484)(H, 395, 469)(H, 396, 461)(H, 397, 474)(H, 398, 485)(H, 399, 489)(H, 400, 499)(H, 401, 430)(H, 402, 479)(H, 403, 480)(H, 404, 500)(H, 405, 463)(H, 406, 493)(H, 431, 432)(H, 433, 434)(H, 435, 436)(H, 437, 438)(H, 439, 440)(H, 441, 442)(H, 443, 444)(H, 505, 506)(H4, 327, 328, 339)(H4, 329, 330, 340)(H4, 331, 332, 341)(H4, 333, 334, 342)(H4, 335, 336, 343)(H4, 337, 338, 344)/t162-, 163-, 164-, 165-, 166-, 167-, 168-, 169+, 170+, 171+, 182-, 183-, 184-, 185-, 186-, 187-, 188-, 189-, 190-, 191-, 192-, 193-, 194-, 195-, 196-, 197-, 198-, 199-, 200-, 201-, 202-, 203-, 204-, 205-, 206-, 207-, 208-, 209-, 210-, 211-, 212-, 213-, 214-, 215-, 216-, 217-, 218-, 219-, 220-, 221-, 222-, 223-, 224-, 225-, 226-, 227-, 228-, 229-, 246-, 247-, 248-, 249-, 250-, 251-, 252-/m0/s1
InChIKey CYHWAVCMOCQGEC-JKQNXSOYSA-N
Isomeric SMILES CC[C@H](C)[C@@H]1NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](Cc6ccc(O)cc6)NC(=O)[C@H](Cc7ccccc7)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]8CSSC[C@H](NC(=O)[C@H](Cc9ccc(O)cc9)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Ccccccc)C(=O)N[C@@H](C(C)C)C(=O)N8)C(=O)N[C@@H](Ccccccc)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N)C(=O)N[C@@H](C)C(=O)NCCC[C@H]C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCCC[C@H]C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)[C@@H](C)O

Description

Insulin Like Growth Factor (IGF)-1 DES is a 67 amino acid residue analogy to native IGF-1, which has been documented as an agent for inducing hyperplasia and stimulating cellular proliferation1. By truncating the original IGF-1 polypeptide – a 70 amino acid residue sequence – to just 67 amino acids, retaining residue numbers 4-70 (hence the synonym ‘IGF-1 [4-70]’)2, IGF-1 DES introduces massive enhancements to IGF-1’s biological activity while making marginal improvements to its structural stability, and therefore, residence time, in vivo.

Animal studies have demonstrated the ability of IGF-1 DES to bind directly to natural IGF receptors and stimulate new tissue formation, while inhibiting apoptosis (programmed cell death) in existing tissues3. Especially at muscle cell sites, IGF-1 species are noted to enhance amino acid recruitment, augment the synthesis of new proteins while minimizing the digestion of intracellular protein as a fuel source. Instead, fat deposits are used as energy sources while IGF species are biochemically active4.

Product Comparison

IGF-1 is a key factor in mediating of growth-promoting effects of growth hormone (GH)5. This particular IGF-1 species was developed in order to avoid interaction with IGFBPs (Insulin Like Growth Factor Binding Proteins), which are known to hinder the activity of native IGF-1 over time6. By avoiding this interplay IGF-1 DES is capable of achieving highly active, unimpeded biological activity, which leads to its utility as a fast-acting facilitator of GH-stimulated biochemical activity.

IGF-1 DES and IGF-1 LR3 have both been shown to be more active relative to native IGF-1 when it comes to stimulating new cell growth in animal trials. Compared to IGF-1 LR3, IGF-1 DES is considered to be multi-fold more active as a stimulant of acute hypertrophy7.

Studies investigating the effects of concurrent IGF-1 species and GH (or GH secretagogue) administration have identified their synergy5 in promoting the development of lean body mass and reduction of fat stores in animal test subjects.

Synonyms:

Insulin Like Growth Factor-1 DES; IGF-1 DES; IGF-1 DES 1-3; IGF-1 DES (1-3); DES 1-3; DES 1-3, DES (1-3), IGF-1 (4-70); Somatomedin C analogue; Detropin

Peer-Reviewed Sources:


  1. Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., & Rosenthal, N. (2001). Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nature genetics, 27(2), 195-200. ↩︎
  2. Shavlakadze, T., Chai, J., Maley, K., Cozens, G., Grounds, G., Winn, N., & Grounds, M. D. (2010). A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo. Journal of cell science, 123(6), 960-971. ↩︎
  3. Tavakkol, A., Elder, J. T., Griffiths, C. E., Cooper, K. D., Talwar, H., Fisher, G. J., & Voorhees, J. J. (1992). Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. Journal of Investigative Dermatology, 99(3), 343-349. ↩︎
  4. LeRoith, D., & Yakar, S. (2007). Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nature Clinical Practice Endocrinology & Metabolism, 3(3), 302-310. ↩︎
  5. Berryman, D. E., Christiansen, J. S., Johannsson, G., Thorner, M. O., & Kopchick, J. J. (2008). Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Hormone & IGF Research, 18(6), 455-471. ↩︎
  6. Francis, G. L., Ross, M., Ballard, F. J., Milner, S. J., Senn, C., McNeil, K. A., & Wells, J. R. E. (1992). Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. Journal of molecular endocrinology, 8(3), 213-223. ↩︎
  7. Ding, H. U., Gao, X. L., Hirschberg, R., Vadgama, J. V., & Kopple, J. D. (1996). Impaired actions of insulin-like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect. Journal of Clinical Investigation, 97(4), 1064. ↩︎

All literature, information, and data, provided on this website are for informational and educational purposes only.

Accurate research is our priority.

Same Day Shipping
We offer same day shipping on all orders of in stock items placed before 12:00pm EST.
Dedicated Service
Our team is readily available to assist with all of your customer service requests.
Free Shipping
We've got you covered! Free shipping is available on any order over $50.
Earn Rewards
Earn points every time you buy from us and use them towards future orders!
Extreme Peptide vial with logo and indicators
Be the first to know

Get 25% off your first order and all the latest information on events, sales, & offers.

We care about keeping your data private. Read our Privacy Policy.