- 1 mg per vial
Free & Fast
Free & Fast
|Physical Appearance||Fine White Lyophilized Powder|
|Stability||Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C|
Insulin Like Growth Factor (IGF)-1 LR3 is an 83 amino acid residue analogue of native IGF-1, which has been documented as an agent for inducing hyperplasia and stimulating cellular proliferation1. By modifying the original IGF-1 polypeptide – a 70 amino acid residue sequence – with a 13 amino acid b-terminus extension and a substitution of Arg for Glu at position 3 (hence the synonym Long Arg3)2, IGF-1 LR3 introduces enhancements to IGF-1’s biological activity while improving its structural stability, and therefore, residence time, in vivo.
Animal studies have demonstrated the ability of IGF-1 LR3 to bind directly to natural IGF receptors and stimulate new tissue formation, while inhibiting apoptosis (programmed cell death) in existing tissues3. Especially at muscle cell sites, IGF-1 species are noted to enhance amino acid recruitment, augment the synthesis of new proteins while minimizing the digestion of intracellular protein as a fuel source. Instead, fat deposits are used as energy sources while IGF-1 species are biochemically active4.
IGF-1 is a key factor in mediating the growth-promoting effects of growth hormone (GH) 5. This particular IGF-1 species was developed in order to avoid interaction with IGFBPs (Insulin Like Growth Factor Binding Proteins), which are known to hinder the activity of native IGF-1 over time6. By avoiding this interplay, IGF-1 LR3 is capable of achieving a very long half-life, which leads to its utility as a long-acting, extremely active facilitator of GH-stimulated anabolic activity.
Compared to IGF-1 DES, IGF-1 LR3 is considered to be less active as a stimulant of acute hyperplasia. This said, IGF-1 LR3 with its sustained in vivo activity is able to induce hypertrophic activity over long periods of time, whereas native IGF-1 and IGF-1 DES lack this functionality7.
IGF-1 LR3 and IGF-1 DES have both been demonstrated as more active biological agents relative to native IGF-1 when it comes to stimulating new cell growth in animal trials.
Studies investigating the effects of concurrent IGF-1 species and GH (or GH secretagogue) administration have identified their synergy5 in promoting the development of lean body mass and reduction of fat stores in test subjects.
Insulin Like Growth Factor-1 LR3; IGF-1 Long R3; IGF-1 Long Arg3;
Somatomedin C analogue; Itropin
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