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GHRP-2

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Concentration
5 mg per vial
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This product is prepared for LABORATORY RESEARCH USE ONLY and may not be used for other purposes.

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Properties

Molecular Formula C45H55N9O6
Molecular Weight 818.0
Monoisotopic Mass 817.42753051
Polar Area 256
Complexity 1440
XLogP 2.5
Heavy Atom Count 60
Hydrogen Bond Donor Count 9
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 21
Physical Appearance Fine White Lyophilized Powder
Stability Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS GHRP-2 Laboratory Chemical Safety Summary

Identifiers

CID 6918245
CAS 158861-67-7
InChI InChI=1S/C45H55N9O6/c1-27(47)41(56)52-38(24-30-19-20-31-14-6-7-15-32(31)22-30)43(58)50-28(2)42(57)53-39(25-33-26-49-35-17-9-8-16-34(33)35)45(60)54-37(23-29-12-4-3-5-13-29)44(59)51-36(40(48)55)18-10-11-21-46/h3-9, 12-17, 19-20, 22, 26-28, 36-39, 49H, 10-11, 18, 21, 23-25, 46-47H2, 1-2H3, (H2, 48, 55)(H, 50, 58)(H, 51, 59)(H, 52, 56)(H, 53, 57)(H, 54, 60)/t27-, 28+, 36+, 37-, 38-, 39+/m1/s1
InChIKey HRNLPPBUBKMZMT-RDRUQFPZSA-N
Isomeric SMILES C[C@H](C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCCN)C(=O)N)N
Canonical SMILES CC(C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCCN)C(=O)N)N
IUPAC Name (2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-aminopropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

2D Structure

Generated by Extreme Peptide with Open Babel, version 2.3.1, http://openbabel.org (accessed June 28, 2022)

GHRP-2 2D molecular structure vector generated with oBabel

Description

Growth Hormone Releasing Peptide 2 (GHRP-2) is a synthetic, 6-amino acid sequence, which is analogous to the naturally occurring protein met-enkephalin1. GHRP-2 has been shown to be an agonist of ghrelin2, which binds strongly with the growth hormone (GH) secretagogue receptor (ghrelin receptor), stimulating potent GH secretion and appetite stimulation in animal test subjects3.

GHRP-2 is known to be a non-lipogenic protein4, meaning that its administration does not induce fat storage. The promotion of lean body mass and improved appetite has been observed in laboratory test animals.

Product Comparison

GHRP-2, a second generation GHRP species, is celebrated as a stimulator of long-sustained GH release (unlike first generation GHRP’s like GHRP-6) and has been shown to increase IGF-1 (Insulin-like Growth Factor 1) levels simultaneously5. GHRP-2 is considered to be a ‘true’ GH secretagogue, reflecting its ability to stimulate the natural, body-mediated production of GH rather than introducing exogenous, synthetic agents to a physiological system.

The GHRP Family

The GHRP family of proteins is distinct from growth hormone releasing hormones (GHRH or GHRF) in that they share no sequence relation and derive their function through action at a completely different receptor, the ghrelin receptor6. The GHRP family is unique in that they lack opiate activity, though they are analogues of species that bear this quality7.

Synonyms:

Growth Hormone Releasing Peptide-2; GHRP2; GHRP 2; Pracrin; Pralmorelin; KP 1;

Peer-Reviewed Sources:


  1. McDowell RS, Elias KA, Stanley MS, Burdick DJ, Burnier JP, Chan KS, Fairbrother WJ, Hammonds RG, Ingle GS, Jacobsen NE (1995). Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation. Proc Natl Acad Sci USA, 92:11165-11169. ↩︎
  2. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402(6762), 656-660. ↩︎
  3. Mericq, V., Cassorla, F., Bowers, C. Y., Avila, A., Gonen, B., & Merriam, G. R. (2003). Changes in appetite and body weight in response to long-term oral administration of the ghrelin agonist GHRP-2 in growth hormone deficient children. Journal of Pediatric Endocrinology and Metabolism,16(7): 981-986. ↩︎
  4. Tschöp, Matthias, David L. Smiley, and Mark L. Heiman. “Ghrelin induces adiposity in rodents.” Nature 407.6806 (2000): 908-913. ↩︎
  5. Thomas, A., Kohler, M., Mester, J., Geyer, H., Schänzer, W., Petrou, M. and Thevis, M. (2010), Identification of the growth-hormone-releasing peptide-2 (GHRP-2) in a nutritional supplement. Drug Test Analysis, 2: 144–148. ↩︎
  6. Granado, M., Priego, T., Martín, A. I., Villanua, M. A., & López-Calderón, A. (2005). Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. American Journal of Physiology-Endocrinology and Metabolism, 288(3), E486-E492. ↩︎
  7. Casanueva, F. F., & Dieguez, C. (1999). Growth hormone secretagogues: physiological role and clinical utility. Trends in Endocrinology & Metabolism,10(1), 30-38. ↩︎

All literature, information, and data, provided on this website are for informational and educational purposes only.

Accurate research is our priority.

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