- 2 mg per vial
Free & Fast
Free & Fast
|Heavy Atom Count||52|
|Hydrogen Bond Donor Count||8|
|Hydrogen Bond Acceptor Count||8|
|Rotatable Bond Count||19|
|Physical Appearance||Fine White Lyophilized Powder|
|Stability||Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C|
|PubChem LCSS||Ipamorelin Laboratory Chemical Safety Summary|
|InChI||InChI=1S/C38H49N9O5/c1-38(2, 41)37(52)47-32(21-28-22-42-23-43-28)36(51)46-31(20-25-15-16-26-12-6-7-13-27(26)18-25)35(50)45-30(19-24-10-4-3-5-11-24)34(49)44-29(33(40)48)14-8-9-17-39/h3-7, 10-13, 15-16, 18, 22-23, 29-32H, 8-9, 14, 17, 19-21, 39, 41H2, 1-2H3, (H2, 40, 48)(H, 42, 43)(H, 44, 49)(H, 45, 50)(H, 46, 51)(H, 47, 52)/t29-, 30+, 31+, 32-/m0/s1|
Generated by Extreme Peptide with Open Babel, version 2.3.1, http://openbabel.org (accessed June 28, 2022)
Ipamorelin is a synthetic 5 amino acid sequence developed as a small molecule, chemically stabilized analogy to the naturally occurring protein ghrelin1. Ipamorelin is a member of a classification of agents called growth hormone (GH) secretagogues that were collectively developed in an effort to artificially stimulate the release of GH2. Ipamorelin is known to bind with the GH secretagogue receptor (ghrelin receptor) directly3, stimulating potent GH secretion in animal test subjects. Unlike its native analogy, ghrelin, Ipamorelin is a non-lipogenic peptide and suppresses somatostatin-induced regulation of GH production4.
The promotion of improved strength, increased muscle mass to body fat ratio, and the encouragement of good joint and connective tissue health has been observed in animal trials where high levels of GH release has been induced5. Ipamorelin, specifically, has been shown to also have a positive effect on bone growth in rats6.
Similar to other agents of GH release, Ipamorelin acts on the anterior pituitary gland1. Ipamorelin’s mechanism of action is very similar to GHRP-2, being a ‘true’ GH secretagogue, reflecting its ability to stimulate the natural, body-mediated production of GH rather than introducing exogenous, synthetic agents to a physiological system.
Like GHRP-6 and GHRP-2, Ipamorelin acts synergistically with growth hormone releasing hormone (GHRH) or any of its analogies, like Sermorelin or CJC-1295, to achieve a very potent release of GH7. In light of this observation, it has been possible for researchers to administrate GHRH’s or GHRH analogies with Ipamorelin concurrently in order to achieve an additive positive effect on GH release.
Unlike GHRP-6 and GHRP-2, which are known to release prolactin and cortisol along with GH, Ipamorelin is specific in its release of GH through a broad spectrum of doses1.
The GHRP family of proteins is distinct from GHRH’s (or GHRFs) in that they share no sequence relation and derive their function through action at a completely different receptor, the ghrelin receptor8. The GHRP family is unique in that they lack opiate activity, though they are analogues of species that bear this quality2.
Ipamorelin Acetate, IPAM, NNC-26-0161
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