- 2 mg per vial
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|Physical Appearance||Fine White Lyophilized Powder|
|Solubility||100 μg/mL sterile diluent (distilled de-ionized water)|
|Stability||Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.|
|Molar Mass||2867.2 g/mol|
Polyethylene Glycol (PEG) Mechano Growth Factor (MGF) is an isoform of Insulin Like Growth Factor 1 (IGF-1) comprised of 24 amino acid residues that is stabilized by a biocompatible polymer coating (PEG). The C-terminal residue sequence of MGF infers the characteristics that make this peptide unique from IGF-11.
A natural form of MGF is expressed in muscle tissues in response to the overburdening or damage of these cells2. MGF has been found to induce the stimulation of repair, regrowth, and the formation of new cells in response to stress3. This process is called hypertrophy (or hyperplasia) and is crucial in the gaining of muscle mass.
The natural production of MGF stimulates the recruitment of undamaged cells to give rise to new muscle tissues, while a liver-derived variant of this agent (IGF-1Ea) initiates the upregulation – or positive feedback control – of protein synthesis4. Through these biochemical pathways, MGF is thought to be the primary mechanism by which the body naturally produces new muscle tissue.
Animal studies have shown MGF as an active neuroprotective agent5 and a promoter of conserved skeletal health6. Also, reinforcing its functionality as an agent of muscle tissue repair, MGF has been found to be active in coordinating the repair of heart muscle tissue following myocardial infarction (heart attack)7.
Though IGF-1 and MGF are very similar in origin and in (partial) structure, the two agents have very different mechanisms of action. Researchers have expressed that these two agents show great synergy and have observed enhanced rates in muscle growth while both IGF-1 LR3 (or IGF-1 DES) and MGF have been administrated together in animal subjects.
PEG MGF is much more stable than unprotected MGF, which infers a much longer residence time in the bloodstream. Preference for MGF’s ‘burst’ profile or PEG MGF’s sustained profile of activity must be determined by the research intent.
Pegylated MGF, PEG IGF-1 Ec; Pegylated MGF Splice Variant of IGF-;
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